The effect of metal-chelating polymers (MCPs) for 111In complexed via the streptavidin-biotin system to trastuzumab Fab fragments on tumor and normal tissue distribution in mice.
Identifieur interne : 000330 ( Main/Exploration ); précédent : 000329; suivant : 000331The effect of metal-chelating polymers (MCPs) for 111In complexed via the streptavidin-biotin system to trastuzumab Fab fragments on tumor and normal tissue distribution in mice.
Auteurs : RBID : pubmed:22907419English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal, Humanized (chemistry), Antibodies, Monoclonal, Humanized (pharmacokinetics), Antineoplastic Agents (chemistry), Antineoplastic Agents (pharmacokinetics), Biotin (chemistry), Cell Line, Tumor, Chelating Agents (chemistry), Female, Humans, Immunoconjugates (chemistry), Immunoconjugates (pharmacokinetics), Immunoglobulin Fab Fragments (chemistry), Indium Radioisotopes (chemistry), Indium Radioisotopes (pharmacokinetics), Mice, Mice, Inbred BALB C, Mice, Nude, Ovarian Neoplasms (diagnosis), Ovarian Neoplasms (drug therapy), Pentetic Acid (analogs & derivatives), Polymers (chemistry), Streptavidin (chemistry).
- MESH :
- chemical , analogs & derivatives : Pentetic Acid.
- chemical , chemistry : Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Biotin, Chelating Agents, Immunoconjugates, Immunoglobulin Fab Fragments, Indium Radioisotopes, Polymers, Streptavidin.
- chemical , pharmacokinetics : Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Immunoconjugates, Indium Radioisotopes.
- diagnosis : Ovarian Neoplasms.
- drug therapy : Ovarian Neoplasms.
- Animals, Cell Line, Tumor, Female, Humans, Mice, Mice, Inbred BALB C, Mice, Nude.
Abstract
To study the effects of backbone composition and charge of biotin-functionalized metal-chelating polymers (Bi-MCPs) for (111)In complexed to streptavidin (SAv)-trastuzumab Fab fragments on tumor and normal tissue localization.
DOI: 10.1007/s11095-012-0853-y
PubMed: 22907419
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The effect of metal-chelating polymers (MCPs) for 111In complexed via the streptavidin-biotin system to trastuzumab Fab fragments on tumor and normal tissue distribution in mice.</title><author><name sortKey="Boyle, Amanda J" uniqKey="Boyle A">Amanda J Boyle</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario M5S 3M2, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario M5S 3M2</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Peng" uniqKey="Liu P">Peng Liu</name></author><author><name sortKey="Lu, Yijie" uniqKey="Lu Y">Yijie Lu</name></author><author><name sortKey="Weinrich, Dirk" uniqKey="Weinrich D">Dirk Weinrich</name></author><author><name sortKey="Scollard, Deborah A" uniqKey="Scollard D">Deborah A Scollard</name></author><author><name sortKey="Ngo Njock Mbong, Ghislaine" uniqKey="Ngo Njock Mbong G">Ghislaine Ngo Njock Mbong</name></author><author><name sortKey="Winnik, Mitchell A" uniqKey="Winnik M">Mitchell A Winnik</name></author><author><name sortKey="Reilly, Raymond M" uniqKey="Reilly R">Raymond M Reilly</name></author></titleStmt><publicationStmt><date when="2013">2013</date><idno type="doi">10.1007/s11095-012-0853-y</idno><idno type="RBID">pubmed:22907419</idno><idno type="pmid">22907419</idno><idno type="wicri:Area/Main/Corpus">000B12</idno><idno type="wicri:Area/Main/Curation">000B12</idno><idno type="wicri:Area/Main/Exploration">000330</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Monoclonal, Humanized (chemistry)</term><term>Antibodies, Monoclonal, Humanized (pharmacokinetics)</term><term>Antineoplastic Agents (chemistry)</term><term>Antineoplastic Agents (pharmacokinetics)</term><term>Biotin (chemistry)</term><term>Cell Line, Tumor</term><term>Chelating Agents (chemistry)</term><term>Female</term><term>Humans</term><term>Immunoconjugates (chemistry)</term><term>Immunoconjugates (pharmacokinetics)</term><term>Immunoglobulin Fab Fragments (chemistry)</term><term>Indium Radioisotopes (chemistry)</term><term>Indium Radioisotopes (pharmacokinetics)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Nude</term><term>Ovarian Neoplasms (diagnosis)</term><term>Ovarian Neoplasms (drug therapy)</term><term>Pentetic Acid (analogs & derivatives)</term><term>Polymers (chemistry)</term><term>Streptavidin (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Pentetic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term><term>Antineoplastic Agents</term><term>Biotin</term><term>Chelating Agents</term><term>Immunoconjugates</term><term>Immunoglobulin Fab Fragments</term><term>Indium Radioisotopes</term><term>Polymers</term><term>Streptavidin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term><term>Antineoplastic Agents</term><term>Immunoconjugates</term><term>Indium Radioisotopes</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Ovarian Neoplasms</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Ovarian Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Female</term><term>Humans</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Nude</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To study the effects of backbone composition and charge of biotin-functionalized metal-chelating polymers (Bi-MCPs) for (111)In complexed to streptavidin (SAv)-trastuzumab Fab fragments on tumor and normal tissue localization.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">22907419</PMID><DateCreated><Year>2012</Year><Month>12</Month><Day>18</Day></DateCreated><DateCompleted><Year>2013</Year><Month>06</Month><Day>03</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1573-904X</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>1</Issue><PubDate><Year>2013</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Pharmaceutical research</Title><ISOAbbreviation>Pharm. Res.</ISOAbbreviation></Journal><ArticleTitle>The effect of metal-chelating polymers (MCPs) for 111In complexed via the streptavidin-biotin system to trastuzumab Fab fragments on tumor and normal tissue distribution in mice.</ArticleTitle><Pagination><MedlinePgn>104-16</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s11095-012-0853-y</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">To study the effects of backbone composition and charge of biotin-functionalized metal-chelating polymers (Bi-MCPs) for (111)In complexed to streptavidin (SAv)-trastuzumab Fab fragments on tumor and normal tissue localization.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Bi-MCPs were synthesized with a polyacrylamide [Bi-PAm(DTPA)(40)], polyaspartamide [Bi-PAsp(DTPA)(33)] or polyglutamide [Bi-PGlu(DTPA)(28)] backbone and harboured diethylenetriaminepentaacetic acid (DTPA) chelators for (111)In. Bi-PAm(DTPA)(40) had a net negative charge; Bi-PAsp(DTPA)(33) and Bi-PGlu(DTPA)(28) were zwitterionic with a net neutral charge. Binding to HER2+ SKOV-3 human ovarian carcinoma cells was determined. Tissue uptake was studied in Balb/c mice by MicroSPECT/CT imaging and biodistribution studies. Tumor and normal tissue uptake of (111)In-labeled Bi-PAsp(DTPA)(33) or Bi-PGlu(DTPA)(28) complexed to SAv-Fab was evaluated 48 h post-injection in athymic mice with subcutaneous SKOV-3 xenografts.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">SAv-Fab complexed to MCPs bound specifically to SKOV-3 cells; but specific binding was decreased 2-fold. Liver uptake was 5-13 fold higher for Bi-PAm(DTPA)(40) than Bi-PAsp(DTPA)(33) and Bi-PGlu(DTPA)(28) but was reduced by decreasing negative charges by saturation with indium. (111)In-Bi-PAsp(DTPA)(33) complexed to SAv-Fab accumulated in SKOV-3 tumors; low tumor uptake was found for (111)In-Bi-PGlu(DTPA)(28)-SAv-Fab.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Zwitterionic MCPs composed of polyaspartamide with a net neutral charge are most desirable for constructing radioimmunoconjugates.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Boyle</LastName><ForeName>Amanda J</ForeName><Initials>AJ</Initials><Affiliation>Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario M5S 3M2, Canada.</Affiliation></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Peng</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Yijie</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Weinrich</LastName><ForeName>Dirk</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Scollard</LastName><ForeName>Deborah A</ForeName><Initials>DA</Initials></Author><Author ValidYN="Y"><LastName>Ngo Njock Mbong</LastName><ForeName>Ghislaine</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Winnik</LastName><ForeName>Mitchell A</ForeName><Initials>MA</Initials></Author><Author ValidYN="Y"><LastName>Reilly</LastName><ForeName>Raymond M</ForeName><Initials>RM</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>08</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Pharm Res</MedlineTA><NlmUniqueID>8406521</NlmUniqueID><ISSNLinking>0724-8741</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Antibodies, Monoclonal, Humanized</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Antineoplastic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Chelating Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Immunoconjugates</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Immunoglobulin Fab Fragments</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Polymers</NameOfSubstance></Chemical><Chemical><RegistryNumber>6SO6U10H04</RegistryNumber><NameOfSubstance>Biotin</NameOfSubstance></Chemical><Chemical><RegistryNumber>7A314HQM0I</RegistryNumber><NameOfSubstance>Pentetic Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>9013-20-1</RegistryNumber><NameOfSubstance>Streptavidin</NameOfSubstance></Chemical><Chemical><RegistryNumber>P188ANX8CK</RegistryNumber><NameOfSubstance>trastuzumab</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Antibodies, Monoclonal, Humanized</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName><QualifierName MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Antineoplastic Agents</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName><QualifierName MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Biotin</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Chelating Agents</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Immunoconjugates</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName><QualifierName MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Immunoglobulin Fab Fragments</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName><QualifierName MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mice, Nude</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Ovarian Neoplasms</DescriptorName><QualifierName MajorTopicYN="N">diagnosis</QualifierName><QualifierName MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Pentetic Acid</DescriptorName><QualifierName MajorTopicYN="N">analogs & derivatives</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Polymers</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Streptavidin</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>4</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>8</Month><Day>2</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2012</Year><Month>8</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>8</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>8</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>6</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1007/s11095-012-0853-y</ArticleId><ArticleId IdType="pubmed">22907419</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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